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Alan Franciscus

Editor-in-Chief

HCV Advocate



Monday, July 27, 2015

A Brief Overview of Liver Toxic Herbs —Alan Franciscus, Editor-in-Chief

Originally Published July 1, 2015

A recent article appeared in Gastroenterology that provided an overview of herbal products. This review will focus on the important issues regarding the lack of standardization, possible contamination, some deceptive claims and a list of the herbs that have the most potential to harm the liver.

In the February 2015 edition of the HCV Advocate Mid-Month Newsletter, I wrote “Herbal Supplement Crackdown.”  The article was about four major chains selling herbal supplements in New York State that contained substances not listed on the package label.  Even more disconcerting was that many of the listed herbs when tested, could not be verified as being the actual labeled herbs. 
Some of the important issues raised in the current study included:
 
Standardization:
There are many factors that affect the potency of herbs such as what season grown, location planted and how much sun the herbs receive, fertilizer (and how much) used and many additional factors. 
For instance, a list of 25 commercial ginseng products from a local health food store was analyzed for ingredients—the ginseng concentrations were different than listed on the label. The difference in the concentrations could be correlated to the standardizations issues listed above.

Contamination and Adulteration:
Herbal products were tested and found to have pesticides and toxins as well as unlabeled drugs in the herbal products.  These types of issues were also found in the herbs analyzed in the New York herbal crackdown. 

Deceptive Marketing:
There have been advertisements that promote the use of herbs stating that some herbal products can help to treat certain conditions and even cure viral infections.  Herbs may provide some relief from particular illnesses and provide supportive care.  However, there never has been a study that has shown that an herb can cure a viral disease such as hepatitis C.  Be careful about these types of claims.

Most Common Liver Toxic Herbs:
The herbs listed below are the most common herbs that have been found to cause liver toxicity, liver injury, possible liver failure and death.  I have listed the common name (bolded), scientific name and the most common ailments the herb is used to treat:
  • Black cohosh (Cimicifuga racemose):  menopausal symptoms
  • Chaparral (Larrea tridentate): weight loss, rheumatic pain, antibiotic
  • Comfrey (Symphyturn officinale): Wound healing
  • Germander (Teucrium chamaedrys):  Weight loss
  • Greater celandine (Chelidonium majus):  Liver and biliary tract disease
  • Green tea extract (Camellia sinensis): General health, weight loss
  • Herbalife product line (Multi-ingredient): Mental health and weight loss
  • Kava kava (Piper methysticum):  mental health and well-being
  • Hydroxycut (multi-ingredient):  Weight loss
  • Oxy-Elite Pro (multi-ingredient):  Performance-enhancement,  weight loss
  • Saw palmetto (Serenoa repens):  Prostate disease
The good news about herbs is that the New York attorney general and 13 other states are petitioning Congress to investigate the herbal supplement industry.  Additionally, the states are requesting the Food and Drug Administration to provide more oversight to the herbal supplements industry.  Until that time, it is up to the consumer to advocate for themselves, dig deep and to stick to the old warning to consumers—buyer beware.

Resources:
http://hcvadvocate.org/news/newsLetter/2015/advocate0715.html#1

Sunday, July 26, 2015

New Zealand: Cost keeps cure out of reach for those with Hepatitis C

Craig Hopkins, 52, nearly died from liver failure after contracting Hepatitis C virus (HCV) from an amateur tattoo. His new liver developed HCV but was finally cured after treatment with a new unsubsidised drug made available on compassionate grounds.

Now Hepatitis C free, the 52-year-old is calling for Sovaldi (sofosbuvir) and Harvoni (ledipasvir/sofosbuvir) to be made available in New Zealand.

"I reckon it's really sad the drugs are not available. If they were, it would free up the operating tables and they wouldn't need to do so many liver transplants."

Read more...

Street Art Fair Raises Awareness About ‘Silent Killer’ Hepatitis C

DENVER (CBS4) – Local artists spent Sunday creating a mural to raise awareness about Hepatitis C. It’s a disease that patients call a silent killer.

Patients and survivors came out to the event to support World Hepatitis Day, including Rhonda Robineau. Today she is happy and healthy, but it wasn’t always that way.

Read more ...

Ireland: Faithfull promotes Hepatitis C awareness week

Singer songwriter Marianne Faithfull is set to front Ireland’s
first campaign to promote awareness of hepatitis C.

The 68-year-old will front The National Hepatitis C Awareness Week. The campaign takes place from July 27 to 31, and Faithfull will be the guest speaker at the launch of the campaign tomorrow at 6pm in the Smock Alley Theatre in Dublin.

Hepatitis C is a viral infection that affects the liver, causing it to become inflamed and not work as effectively in the body. It can be contracted via blood-to-blood contact with an infected person’s blood.

Speaking to The Sunday Times, Faithfull said she was diagnosed with the virus 23 years ago.

Read more...

Saturday, July 25, 2015

Canada: Quebec to start reimbursing for 'revolutionary' Hepatitis C treatment

Quebec has decided to reimburse “revolutionary” drugs that can cure Hepatitis C, but only for the sickest patients at first.

According to the rules adopted by the Régie de l’assurance maladie du Québec, some Quebecers with the disease will have to wait three years before getting access to new treatments.

The measures concern two drugs called Harvoni and Holkira Pak that are supposed to cure the condition in 8-12 weeks.

Read more...

Tuskegee launches hepatitis C virus testing initiative

In honor of the third annual National African American Hepatitis C Action Day today, the City of Tuskegee is taking steps to eradicate the hepatitis C virus (HCV) infection in its community, beginning with testing.

Mayor Johnny Ford of Tuskegee joined with national and local health leaders to discuss starting an initiative to diagnose and treat those infected with HCV in his area Friday morning.


C. Virginia Fields, president and CEO of the National Black Leadership Commission on AIDS, joined Ford in announcing that something must be done to counteract the spread of hepatitis C in the African American community.

Read more...

Friday, July 24, 2015

Bristol-Myers wins approval for 1st hepatitis C type 3 drug

TRENTON, N.J. (AP) - An experimental drug for one of the hardest-to-treat types of hepatitis C has been approved by the Food and Drug Administration, adding to the surge of new options - all much more effective but extremely costly - for patients with the liver-destroying virus.

Daklinza, developed by New York-based Bristol-Myers Squibb Co., is the first drug approved to treat genotype 3, the second-most-common form. About 10 percent of Americans with hepatitis C have genotype 3.

Because genotype 3 is so hard to cure and damages the liver more quickly than other types, Daklinza is to be taken with Sovaldi, one of two blockbuster hepatitis C drugs sold by market leader Gilead Sciences Inc., along with Harvoni.

Meanwhile, the FDA on Friday also approved Technivie, a combination drug made by AbbVie Inc. for one of the least common forms of hepatitis C, genotype 4. Technivie also must be taken with a second drug, a much-older, generic pill called ribavirin.

Read more..