New treatment was given to the patients after doctors warned they were not responding to other drugs.
The treatment, which costs around €45,000 to €55,000 per patient was given to the patients after doctors warned they were not responding to other drugs.
Dr Suzanne Norris, a gastroenterologist at St James's Hospital in Dublin, said the patients will continue to be monitored over the coming months to determine their response.
Earlier this year Health Minister Leo Varadkar said a programme was being put in place to provide early access to the powerful new direct-acting anti-viral drugs for Hepatitis C patients with the greatest clinical need, due to the advanced nature of their condition.
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